苏州大学药学院

张雪侬

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张雪侬,男,1962年天生的,博士,谆谆教诲、博士生解说者。~ 作为学科带头人引进苏州大学药学院;现时是政府开展和变革佣金价钱的专家围攻、政府药审结心新药审评行家围攻,第一批源自举国上下执业药师的专家、中国药学会制药学分支形成盟员,江苏省药学会使服麻醉药科副负责人。政府教育部、政府自然科学基金复习专家、江苏省人事厅、科学技术部和教育部专家。抗传染使服麻醉药学副以蓝色铅笔删改,中国药物预告以蓝色铅笔删改佣金,中国药学注意。《Biomaterials》、《ACS Appl. 马特。 Interfaces和《Int J Pharm.等定期刊物讲师江苏省“333高能级人员培训图谋中青年科学与技术首领与江苏省六大人才。 掌管政府自然科学基金、SCI部科学与技术型中小企业技术革新基金、政府科学与技术大括号标示于图表上与江苏省社会。敷发明专利10余项,授权证6项。指点先生论文,4江苏优良硕士论文,5苏州大学优良硕士学位论文,1本文获江苏大学本科伸出二等奖。,2荣获三奖。荣获中医制药学技先进二等奖1项,苏州科学与技术先进奖二等奖1项,第三名2项。周苏州大学科研奖2次,陈金荣生命科学奖3次。达到预期的目的2017苏州大学的我最喜欢的教导着。

称呼:

苏州大学药学院药学教研组,

苏州工业区仁道199邮递区号:215123

联系电话&描绘:0512-65882087

E-mailzhangxuenong@163.com

zhangxuenong@suda.edu.cn

次要课题轴承:

1、目的印零碎课题

 以紫杉醇、亚德里亚霉素和生殖细胞的细胞质被用作模特儿药物。,配制品与弥撒曲把持课题、起多功用功用的性(包孕体温)/pH感光度、接收器介导、对称体变美毫微米颗粒、脂质体、高分子化合物微胞智能等对象给药零碎,对细胞和畜生举行对象和药效学评价。。内服药物的吸取机制及生物申请度课题:毫微米药物拥护者与对象给药零碎的申请,更妥不溶性药物、低漏吸取性药物的生物申请度课题,并说明其功用机制。。政府重点纪律辐射学作为平台,种类标识表记标帜、药物送的药代动力学和对象性课题。

2、长效新数据与新技术

依托古代丝织物政府工程政府医用生物学,家蚕Bombyx mori丝素胚乳的吸引与升华,改性改性时新生物相容性可毁坏高分子化合物毡,用于微球、透皮给药零碎的药物拥护者,肽、核蛋白质和镇痛药新药。以自然壳多糖为数据经过变美与改性分解的生物可毁坏和功用性高分子为拥护者数据,时新缓释给药零碎的设计与使最优化,分子镜头学。、PET-CT和别的先进技术来探究药物。节约、药物细胞相互功用的评价技术。

率直的放映

1.   掌管“CD147ab介导助手PD-L1化疗/免除集体工作功用ROS敏感的智能精髓对象送零碎,照准号:8177318355万。2018.1-2021.12

2.   掌管“cRGD变美的共调动胚乳抗精髓药siRNA自任命高分子化合物微胞保送零碎的课题2012政府自然科学基金(NO.):81273463),67万。

3.   人源性低密度脂胚乳介导-pH/还雏形UNIKA二维高分子化合物微胞的配制品与课题,照准号:8157178858万。2016.1-2019.12

4.   江苏科学与技术大括号标示于图表上社会开展,人工器官移植药物环孢菌素A自乳化毫微米颗粒的成型技术及新药发展(BE2011670),30

5.   时新抗精髓毫微米长效给药零碎的课题获SCI部科学与技术型中小企业技术革新基金(),出身指定遗传密码:07C26223201333,帮助现款60万。

6.   古代预备技术在国药预备击中要害机动性政府科学与技术大括号标示于图表上),编号:2006BAI09B00,使突出现款620万,提携单位负责人

近五年宣布的代表论文

1.        Yang SD, Wang Y, Ren ZX, Chen MT, Chen WL, Zhang*. Stepwise  pH/reduction- responsive polymeric conjugates for enhanced drug delivery to 精髓。 Materials Science & Engineering C. 2018,82: 234-243  IF 4.16 二区

2.        Yang SD+, Ren ZX, Chen MT,Wang Y,You BG,Chen EL, Qu CX,Liu Y, Zhang XN* Nucleolin-Targeting AS1411-Aptamer-Modified Graft Polymeric Micelle with Dual pH/Redox Sensitivity Designed To Enhance Tumor Therapy through the Codelivery of Doxorubicin/TLR4 siRNA and Suppression of 入侵。 Mol Pharmac 2018, Jan 2;15(1):314-325. doi: 10.1021/acs.molpharmaceut.IF 4.44

3.        Qu CX,Li JZ, Zhou YJ,Yang SD, Chen WL, Li F,You BG, Liu Y,and Zhang XN.Targeted Delivery of Doxorubicin via CD147-Mediated ROS/pH Dual-Sensitive Nanomicelles for the Efficient Therapy of Hepatocellular Carcinoma.The AAPS Journal2018 20:34 DOI: 10.1208/s12248-018-0195-8

4.        Yuan ZQ+,Chen WL+, You BQ,Liu Y, Shu-di Yanga, Li JZa , Zhu WJ, Zhou XF,Liu C,ZhangXN*.Multifunctional nanoparticles co-delivering EZH2 siRNA and etoposide for synergy therapy of orthotopic non-small-cell lung tumor, Journal of Controlled Release, 2017,268:198-211,一区 IF 7.79

5.        Zhu WJ#, Yang SD#, Qu CX, Zhu QL, Chen WL, Li F, Yuan ZQ, Liu Y, You BG, Zhang XN*. Low-density lipoprotein-coupled micelles with reduction and pH dual sensitivity for intelligent 协同发出 of paclitaxel and siRNA to breast 精髓。 Int J Nanomed  2017,12: 3375—3393 IF 4.30 二区

6.        Chen WL, Li F,Tang Y,Yang SD,Li JZ,Yuan ZQ,Liu Y,Zhou XF,Liu C,Zhang XN*.Stepwise pH-responsive nanoparticles for enhanced cellular uptake and on-demand intracellular release of 亚德里亚霉素Int J Nanomed  2017,12: 4241-4256  IF 4.30 二区

7.        Yang, SD#, Zhu WJ#, Zhu QL,Chen WL, Ren ZX, Li F,Yan ZQ, Li JZ,Liu Y, Zhou XF, Liu C, Zhang XN*. Binary-copolymer system base on low-density lipoprotein-coupled N-succinyl chitosan 硫悲哀的的 acid micelles for 协同发出 MDR1 siRNA and paclitaxel, enhances antitumor effects via reducing 药物。 Biomed Mater Res B Appl Biomater. 2017,105(5):1114-1125 IF 3.19 二区

8.        Zhang CG#, Yang SD#, Zhu WJ#, You BG, Liu Y, Yuan ZQ, Chen WL, Li JZ, Zhou XF, Liu C, Zhang XN*. Distinctive polymer micelle designed for siRNA delivery and reversal of MDR1 gene-dependent multidrug resistance.J Biomed Mater Res B Appl Biomater. 2017 ,105(7):2093-2106. IF 3.19二区

9.        Li F#, Chen WL#, You BG,  Liu Y, Yang SD, Yuan ZQ, Zhu WJ, Li JZ, Qu CX, Zhou YJ, Zhou XF, Liu C, Zhang XN*. Enhanced cellular internalization and on-demand intracellular release of doxorubicin by stepwise pH/reduction-responsive 毫微米颗粒。 ACS Appl. 马特。 Interfaces, 2016 ;8(47):32146-32158  IF 7.14 一区

10.    Chen WL#,Yang SD#,Li F#,Li JZ,Yuan ZQ, Zhu WJ, Liu Y, Zhou XF, Liu C, Zhang XN*. Tumor microenvironment-responsive micelles for pinpointed intracellular release of doxorubicin and enhanced anti-cancer effi迟滞。 Int J Pharm. 2016,511: 728740.IF 3.994 二区

11.    Chen WL#Yuan ZQ#, Liu YYang SD, Zhang CG, Li JZ, Zhu WJ, Li F, ZhouXF, Lin YM, ZhangXN*. Liposomes coated with N-trimethyl chitosan to improve the absorption of harmine in vivo and in 外国的。Int J Nanomed.2016, 11:325-336, IF 4.30 二区

12.    Zhu R#, Zhang CG#, Liu Y, Yuan ZQ,Chen WL, Yang SD , Li JZ, Zhu WJ, Zhou XF, YouBG*, Zhang XN*. CD147 monoclonal antibody mediated by chitosan nanoparticles loaded with α-hederin enhances antineoplastic activity and cellular uptakein liver cancer cells. Scientific Reports. 2015, doi: 10.1038/srep17904. SCI三区,IF 4.26

13.    Yuan ZQ, Li JZ, Liu Y, Chen WL, Yang SD, Zhang CG, Zhu WJ, Zhou XF, Liu C, ZhangXN*.Systemic delivery of micelles loading with paclitaxel using N-succinyl-palmitoyl-chitosan decorated with cRGDyK peptide to inhibit non-small-cell lung 社会恶习。 Int J Pharm. 2015  15;492(1-2):141-51. IF 3.994 二区

14.    Zhu QL#, Zhou Y#, Guan M, Zhou XF, Yang SD,Liu Y,Chen WL, Zhang CG, YuanZQ, Liu C,Zhu AJ,Zhang XN*.Low-density lipoproteincoupled N-succinyl chitosan nanoparticles co-delivering siRNA and doxorubicin for hepatocyte-targeted 助手。 Biomaterials, 2014,35(22):5965-5976IF 8.4 一区

15.    BeiYY#,Yuan ZQ#, Zhang L#,Zhou XF, Chen WL, Xia P, Liu Y, You BG, Hu XJ, Zhu QL, Zhang CG, Zhang XN*, Jin Y. Novel Self-assembled Micelles based on Palmitoyl-trimethyl-chitosan for Efficient Delivery of Harmine to Liver 社会恶习。 Expert Opinion on Drug Delivery, 2014,11(6): 843-854IF 5.66 二区

16.    Zhang CG#,Zhu QL#,Zhou Y#, Liu Y, Chen WL, Yuan ZQ, Yang SD, Zhou XF, Zhu AJ, Zhang XN*, Jin Y*.N-Succinyl-chitosan nanoparticles coupled with low-density lipoprotein (低密度脂胚乳) for targeted loaded-osthole delivery to (LDLr)-富 精髓。 Int J Nanomed ,2014, 9:2919-2932  IF 4.30,二区

17.    Bei YY#, Zhou XF#, You BG, Yuan ZQ, Chen WL, Xia P, Liu Y, Jin Y, Hu XJ, Zhu QL, Zhang CG, Zhang XN*, Zhang L*. Application of the central composite design to optimize the preparation of novel micelles of harmine. Int J Nanomed. 2013, 8:1795-1808,二区,IF  4.30

18.    Liu Y#, Wang XQ#, Ren WX, Chen YL, Yu Y, Zhang JK, Bawudong D, Gu JP, Xu XD, Zhang XN*. Novel albendazole-chitosan nanoparticles for intestinal absorption enhancement and hepatic targeting improvement in rats.J Biomed Mater Res B Appl Biomater. 2013 101B(6): 998-1005.二区,IF 2.881

19.    Zhang GY#, Zhou XF#, Zhou XY, Wen QY, You BG, Liu Y, Zhang XN*, Jin Y.Effect of alginate-chitosan sustained release microcapsules for transhepatic arterial embolization in VX2 rabbit liver cancer 模特儿。 J Biomed Mater Res A. 2013 ,101(11):3192-3200. 二区,IF 3.263

20.    Zhu QL#, Zhou Y#, Guan M, Yu DJ, Zhou XF, Liu Y, Xu JY, Wu Y, Gu ZL, Xing KL, Zhu AJ, Chen WL, Shi LS, Zhang XN*, Zhang Q.Hepatocyte-targeted delivery using pH-sensitive liposomes loaded with lactosyl-norcantharitin phospholipid complex: preparation, characterization, and therapeutic evaluation in vivo and in 外国的。  Curr Med Chem. 2012, 19(33):5754-5763 二区 3.455

21.    Guan M, Zhou Y, Zhu QL, Liu Y, Bei YY,Zhang XN*Zhang Q. N-Trimethyl Chitosan Nanoparticle–encapsulated Lactosyl-Norcantharidin for Liver Cancer Therapy with High Targeting 使发生。 Nanomedicine: Nanotechnol. 2012,8:1172-1181,IF 5.671,一区

22.    Ding XY, Hong CJ, Liu Y, Gu ZL, Xing KL, Zhu AJ, Chen WL, Shi LS, Zhang XN*, Zhang Q Pharmacokinetics, tissue distribution, and metabolites of polyvinylpyrrolidone coated norcantharidin chitosan nanoparticle formulation in rats and mice by LC-MS/MS.Int J Nanomed ,2012:7 1723-1735 IF 4.32二区

23.    Guan M, Zhu QL, Liu Y, Bei YY, Gu ZL, Zhang XN*Zhang Q.Uptake and Transport of a Novel Anticancer Drug Delivery System Lactosyl-norcantharidin-associated N-trimethyl Chitosan Nanoparticles across Intestinal Caco-2 Cell Monolayers。 Int J Nanomed ,2012,7:1921-1930IF 4.32,二区

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